UPDATED: 24th August 2007, to reflect Richard Seroter's comment
There is no necessity to explain the importance of caching in any server based developments like BizTalk, ASP .NET etc. You need to plan early in your development cycle to cache resources in order to make most out of your limited server resources.
In BizTalk applications, it's quite common to lookup a data store to pickup a value, at different stages like custom Adapters, Pipelines, Orchestration, etc....
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